The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare provider. How long drug detox takes depends on the substance used, the amount of the substance used and the length of time the person has been using the substance. Symptoms of opiate or heroin withdrawal usually start around hours after the Dr juan rivera Keto The earliest symptoms will usually include aches and pain, fatigue, extreme nausea, sweating, anxiety and insomnia. These symptoms may get worse as time goes on, and new symptoms may pop up, such as stomach pain, chills and digestive issues. While these symptoms may seem daunting, they can be controlled and managed in a professional, medically-supervised setting. A doctor will consider all these factors when estimating how long-lasting and how severe your symptoms may be. Minor withdrawal symptoms usually begin about six hours after your last drink.